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Recombinant Human GMPR Protein (E.coli, His Tag)
SKU: PKSH030542-100
Recombinant Human GMPR Protein (E.coli, His Tag)
| SKU # | PKSH030542 |
| Expression Host | E.coli |
Description
| Synonyms | GMP Reductase 1, GMPR, GMPR1, Guanosine 5'-Monophosphate Oxidoreductase 1, Guanosine Monophosphate Reductase 1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser345 |
| Accession | P36959 |
| Calculated Molecular Weight | 39.2 kDa |
| Observed Molecular Weight | 37 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM Tris, 150mM NaCl, 40% Glycerol, 1mM DTT, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
GMPR; also known as GMPR1; belongs to the IMPDH/GMPR family.This familyofenzymesincludesIMP dehydrogenaseandGMP reductase. These enzymes are involved inpurine metabolism and adopt aTIM barrelstructure. GMPR is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. GMPR functions in the conversion of nucleobase; nucleoside and nucleotide derivatives of G to A nucleotides; and in maintaining the intracellular balance of A and G nucleotides.