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Recombinant Human GSS Protein (His Tag)– MSE Supplies LLC

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Recombinant Human GSS Protein (His Tag)

SKU: PKSH032497-50

  • £43200
  • Save £4900



Recombinant Human GSS Protein (His Tag)

 

SKU # PKSH032497
Expression Host E.coli

 

 

Description

Synonyms GSH Synthetase, GSH-S, GSS, Glutathione Synthase, Glutathione Synthetase
Species Human
Expression Host E.coli
Sequence Ala2-Val474
Accession P48637
Calculated Molecular Weight 53.5 kDa
Observed Molecular Weight 55 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 7.5.
Reconstitution Not Applicable



Background

Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in Glutathione Synthetase can also cause the glutathione synthetase deficiency of erythrocytes, which is a mild form causing hemolytic anemia.