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Recombinant Human GSTP1 Protein– MSE Supplies LLC

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Recombinant Human GSTP1 Protein

SKU: PKSH032496-50

  • £43200
  • Save £4900



Recombinant Human GSTP1 Protein

 

SKU # PKSH032496
Expression Host E.coli

 

 

Description

Synonyms FAEES3, GST class-pi, GST3, GSTP1, GSTP1-1, Glutathione S-transferase P
Species Human
Expression Host E.coli
Sequence Met 1-Glu210
Accession AAH10915.1
Calculated Molecular Weight 23.5 kDa
Observed Molecular Weight 22-25 kDa
Tag None
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution Not Applicable



Background

Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. It thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.