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Recombinant Human HPGDS/GSTS Protein
SKU: PKSH032528-50
Recombinant Human HPGDS/GSTS Protein
| SKU # | PKSH032528 |
| Expression Host | E.coli |
Description
| Synonyms | GST Class-Sigma, GSTS, Glutathione S-Transferase, Glutathione-Dependent PGD Synthase, Glutathione-Requiring Prostaglandin D Synthase, H-PGDS, HPGDS, Hematopoietic Prostaglandin D Synthase, PGDS, PTGDS2, Prostaglandin-H2 D-Isomerase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Leu199 |
| Accession | O60760 |
| Calculated Molecular Weight | 22.3 kDa |
| Observed Molecular Weight | 26 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 7.0. |
| Reconstitution | Not Applicable |
Background
Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydroperoxide.