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Recombinant Human HSPB11 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human HSPB11 Protein (His Tag)

SKU: PKSH032522-50

  • £43300
  • Save £4900



Recombinant Human HSPB11 Protein (His Tag)

 

SKU # PKSH032522
Expression Host E.coli

 

 

Description

Synonyms C1orf41, HSPB11, Heat Shock Protein Beta-11, Hspb11, PP25, Placental Protein 25
Species Human
Expression Host E.coli
Sequence Met 1-Ser144
Accession Q9Y547
Calculated Molecular Weight 18.5 kDa
Observed Molecular Weight 21 kDa
Tag N-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 2mM DTT, 10% Glycerol, pH 8.0.
Reconstitution Not Applicable



Background

Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.