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Recombinant Human HtrA2/Omi Protein (His Tag)
SKU: PKSH033408-50
Recombinant Human HtrA2/Omi Protein (His Tag)
| SKU # | PKSH033408 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | HTRA2, High temperature requirement protein A2, HtrA2, OMI, Omi stress-regulated endoprotease, PRSS25, Serine protease 25, Serine protease HTRA2, Serine proteinase OMI, mitochondrial |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala134-Glu458 |
| Accession | O43464 |
| Calculated Molecular Weight | 36.0 kDa |
| Observed Molecular Weight | 35-43 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 4mM HCl. |
| Reconstitution | Not Applicable |
Background
High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. The protein cleaves THAP5 and promotes its degradation during apoptosis.