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Recombinant Human IFN-λ3/IL-28B Protein (Human Cells, His Tag)(Active)
SKU: PKSH032637-50
Recombinant Human IFN-λ3/IL-28B Protein (Human Cells, His Tag)(Active)
| SKU # | PKSH032637 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Cytokine Zcyto, ZCYTO, IFNL3, IFN-lambda-3, IFN-lambda-4, IL-28B, IL-28C, IL28B, IL28C, Cytokine Zcyto22, IFNL4, IFN-lambda 3, interferon lambda 3, Interferon Lambda-3, Interferon Lambda-4, Interleukin-28B, Interleukin-28C, ZCYTO22 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Val22-Val196 |
| Accession | Q8IZI9 |
| Calculated Molecular Weight | 20.7 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-28B; also known as Cytokine Zcyto22; Interferon lambda-3; Interferon lambda-4; IFNL3; IFNL4; ZCYTO22 and IL28B; is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition; IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.