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Recombinant Human IGFBP-5/IGFBP5 Protein (His Tag)
SKU: PKSH032598-50
Recombinant Human IGFBP-5/IGFBP5 Protein (His Tag)
| SKU # | PKSH032598 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IBP-5, IBP5, IGF-Binding Protein 5, IGFBP-5, IGFBP5, Insulin-Like Growth Factor-Binding Protein 5 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu21-Glu272 |
| Accession | P24593 |
| Calculated Molecular Weight | 29.6 kDa |
| Observed Molecular Weight | 30-40 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed by fibroblasts, myoblasts and Osteosarcoma. It is also present at lower levels in liver, kidney, and brain.