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Recombinant Human IL-1 beta/IL1B Protein (pro form, His Tag)(Active)
SKU: PKSH031840-100
Recombinant Human IL-1 beta/IL1B Protein (pro form, His Tag)(Active)
| SKU # | PKSH031840 |
| Expression Host | E.coli |
Description
| Synonyms | IL1F, IL-1F, pro IL1F, IL-1, IL1-BETA, IL1F2, IL1 beta, IL1B, catabolin, IL-1B, pro Catabolin, pro IL1B, pro IL1F2, pro leukocytic endogenous mediator, pro leukocytic pyrogen, pro lymphocyte activating factor, pro mononuclear cell factor, IL-1F2, IL 1B, IL-1 beta |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser 269(Glu6Lys) |
| Accession | NP_000567.1 |
| Calculated Molecular Weight | 32.3 kDa |
| Observed Molecular Weight | 34 kDa |
| Tag | N-His |
| Bio-activity | Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1R1.The EC50 of human IL1R1 is 0.198 μg/mL. |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).