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Recombinant Human IL-1RL2 Protein (His Tag)(Active)
SKU: PKSH032562-50
Recombinant Human IL-1RL2 Protein (His Tag)(Active)
| SKU # | PKSH032562 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Interleukin-1 receptor-like, IL1RL, IL1RRP, IL-1Rrp, IL1R-rp, IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, IL36R, IL-36 receptor, Interleukin-1 receptor-like 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp20-Tyr337 |
| Accession | Q9HB29 |
| Calculated Molecular Weight | 37.0 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-His |
| Bio-activity | Loaded Anti-Human IL-36R mAb-Fc on Protein A Biosensor, can bind Human IL-1RL2-His with an affinity constant of 0.03 nM as determined in BLI assay. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene; belongs to the interleukin-1 receptor family.IL1RL2 is the receptor for interleukin-36 (IL36A; IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B; MAPK and other pathways.