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Recombinant Human IL-20RB Protein (Fc Tag)
SKU: PKSH032574-50
Recombinant Human IL-20RB Protein (Fc Tag)
| SKU # | PKSH032574 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, PRO, MGC, DIRS, FNDC, fibronectin type III domain containing, IL-20R, IL20RB, DIRS1, FNDC6, IL-20R2, fibronectin type III domain containing 6, hCG_2022374, IL-20 receptor subunit beta, IL-20RB, IL-20R-beta, interleukin-20 receptor II, Interleukin-20 receptor subunit beta, MGC34923, UNQ557, PRO1114 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp30-Ala230 |
| Accession | Q6UXL0 |
| Calculated Molecular Weight | 49.6 kDa |
| Observed Molecular Weight | 60-85 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Interleukin-20 receptor subunit beta（IL20RB） is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family