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Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)(Active)
SKU: PKSH032579-50
Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)(Active)
| SKU # | PKSH032579 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IL23R, IL-23 receptor, IL-23R, Interleukin-23 receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly24-Asp353 |
| Accession | Q5VWK5 |
| Calculated Molecular Weight | 65.0 kDa |
| Observed Molecular Weight | 90-120 kDa |
| Tag | C-Fc |
| Bio-activity | Immobilized Human IL-23R-Fc at 10μg/ml (100 μl/well)can bind Human IL-23-His.The ED50 of Human IL-23-His is 0.248 μg/ml. |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits; the IL12Rβ1 subunit; which is shared with several cytokines; and a subunit that is unique to IL-23. IL23; after binding to IL23R; activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells; NK cells; dendritic cells; and macrophages. In fact; polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis; multiple sclerosis; Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.