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Recombinant Human IL-28B/IFN-lambda-3 protein (His tag)
SKU: PDEH100260-100
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Recombinant Human IL-28B/IFN-lambda-3 protein (His tag)
| SKU # | PDEH100260 |
| Expression Host | E. coli |
Description
| Synonyms | Interleukin-28B;IL-28B;Cytokine Zcyto22;Interferon Lambda-3;Interferon Lambda-4;IFN-Lambda-4;Interleukin-28C;IL-28C;IL28B;IFNL3;IFNL4;IL28C;ZCYTO22 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Val 22-Val 196 |
| Accession | Q8IZI9 |
| Mol_Mass | 19.1 kDa |
| AP_Mol_Mass | 25 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Interleukin-28B; also known as Cytokine Zcyto22; Interferon lambda-3; Interferon lambda-4; IFNL3; IFNL4; ZCYTO22 and IL28B; is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition; IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.