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Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)
SKU: PKSH033944-50
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Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)
| SKU # | PKSH033944 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CDW, IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, IL-7R, IL-7RA, IL-7Rα, Interleukin-7 receptor subunit alpha, IL-7R&, alpha, CD 127, CD127 antigen, IL 7R, IL 7R alpha, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL7Ralpha, Interleukin 7 receptor, Interleukin 7 receptor alpha chain, Interleukin 7 receptor isoform H5 6 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu21-Gly236 |
| Accession | P16871 |
| Calculated Molecular Weight | 25.7 kDa |
| Observed Molecular Weight | 40-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 7 Receptor alpha (IL-7Rα), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.