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Recombinant Human IL17B/IL-17B Protein (Fc Tag)
SKU: PKSH033628-50
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Recombinant Human IL17B/IL-17B Protein (Fc Tag)
| SKU # | PKSH033628 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, PRO, Cytokine ZCYTO, ZCYTO, Cytokine ZCYTO7, IL-17B, IL-20, IL20, NIRF, ZCYTO7, IL17B, UNQ516, PRO1031 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln21-Phe180 |
| Accession | Q9UHF5 |
| Calculated Molecular Weight | 45.1 kDa |
| Observed Molecular Weight | 48 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. In addition to IL-17B, members of the IL-17 family include IL-17A, IL-17C, IL-17D, IL-17E and IL-17F. The six IL-17 cytokines are highly conserved at C terminus, and contain five spatially conserved cysteine residues that mediate dimerization. Expression of IL-17B protein has been reported in neurons, testis, ovary, stomach, pancreas, small intestine and chondrocytes. IL-17B binds to Interleukine-17 receptor B (IL-17 RB) and induces the production of inflammatory cytokines and the infiltration of inflammatory immune cells.