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Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)
SKU: PKSH030736-100
Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)
| SKU # | PKSH030736 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CRL, EVI, UNQ, IL17RH, IL17RB, CRL4, EVI27, IL17BR, IL17RH1, UNQ2501, PRO19612, CRL 4, Cytokine receptor CRL4, EVI 27, IL 17 receptor B, IL 17 receptor homolog 1, IL 17B receptor, IL 17RB, IL 17Rh1, Interleukin 17 receptor B, Interleukin 17 receptor homolog, Interleukin 17 receptor homolog 1, Interleukin 17B receptor, MGC5245 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Gly289 |
| Accession | NP_061195.2 |
| Calculated Molecular Weight | 56.9 kDa |
| Observed Molecular Weight | 67 kDa |
| Tag | C-hFc |
| Bio-activity | Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4. 5-10.4ng/mL. |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.