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Recombinant Human IL17RC Protein (Fc Tag)(Active)
SKU: PKSH031013-100
Recombinant Human IL17RC Protein (Fc Tag)(Active)
| SKU # | PKSH031013 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, IL17RC, UNQ6118, PRO20040, PRO38901, IL17RL, IL17-RL, UNQ6118/PRO20040/PRO38901 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ala 454 |
| Accession | NP_116121.2 |
| Calculated Molecular Weight | 75.3 kDa |
| Observed Molecular Weight | 100-120 kDa |
| Tag | C-hFc |
| Bio-activity | Measured by its ability to bind with recombinant human IL17A-His in a functional ELISA. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Plexin domain-containing protein 1; also known as tumor endothelial marker 3; tumor endothelial marker 7 and PLXDC1 and TEM3; is a secreted; cytoplasm and single-pass type I membrane protein which belongs to theplexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer; and in endothelial cells from primary cancers of the lung; liver; pancreas; breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. PLXDC1 / TEM3 is not detectable in endothelial cells from normal tissue. PLXDC1 / TEM3 plays a critical role in endothelial cell capillary morphogenesis. PLXDC1 / TEM3 may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). PLXDC1 / TEM3 may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (PDR). PLXDC1 / TEM3 interacts with NID1. It may also interact with CTTN.