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Recombinant Human IL18R1/CD218a Protein (His Tag)– MSE Supplies LLC

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Recombinant Human IL18R1/CD218a Protein (His Tag)

SKU: PKSH031254-100

  • £59900
  • Save £6700



Recombinant Human IL18R1/CD218a Protein (His Tag)

 

SKU # PKSH031254
Expression Host HEK293 Cells

 

 

Description

Synonyms IL18R, IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP,  IL-1Rrp1,  IL-18R, IL18R&, alpha, alpha chain, CD218 antigen-like family member A, CDw218a antigen, IL 1Rrp, IL1 receptor related protein, IL1 receptor-related protein, IL-18R1, IL-18R-1, Il18ralpha, IL1R-rp, Interleukin 18 receptor, Interleukin 18 receptor 1, Interleukin-18 receptor 1
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Arg 329
Accession NP_003846.1
Calculated Molecular Weight 37.2 kDa
Observed Molecular Weight 60-70 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.