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Recombinant Human IL18RAP/IL1R7 Protein (His Tag)
SKU: PKSH032568-50
Recombinant Human IL18RAP/IL1R7 Protein (His Tag)
| SKU # | PKSH032568 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IL1R, ACPL, CD218b, CDw218b, IL-18RAcP, IL18RB, IL-18Rbeta, IL-18R-beta, IL-1R7, IL-1R-7, IL-1RAcPL, IL1R7, IL18RAP, IL-1RcPL, CDw218b, IL18R&, beta, Accessory protein like, Accessory protein-like, CD218 antigen-like family member B, I18RA, IL 18RAcP, IL 1R accessory protein like, IL 1R7, IL 1RAcPL, IL-18 receptor accessory protein, IL18Rbeta, IL-1R accessory protein-like, Interleukin 18 receptor accessory protein, Interleukin-1 receptor 7, Interleukin-18 receptor accessory protein, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, Interleukin-18 receptor beta chain |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Phe20-Arg356 |
| Accession | O95256 |
| Calculated Molecular Weight | 39.4 kDa |
| Observed Molecular Weight | 56 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease.