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Recombinant Human IL1R1/CD121a Protein
SKU: PKSH031847-100
Recombinant Human IL1R1/CD121a Protein
| SKU # | PKSH031847 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | D2S, Interleukin-1 receptor type, IL1RT, IL1-R, IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, CD121 antigen-like family member A, IL-1 RI, IL1-R1, IL-1R1, IL-1R-1, IL-1RT1, IL-1RT-1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, IL1RT1, IL-1R type I, IL-1RI |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Thr332 |
| Accession | NP_000868.1 |
| Calculated Molecular Weight | 36.8 kDa |
| Observed Molecular Weight | 56 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.