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Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)(Active)
SKU: PKSH030755-100
Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)(Active)
| SKU # | PKSH030755 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | FIT, DER, IL1RL, IL-1 R, IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, IL-1 R4, DER-4, FIT 1, Growth stimulation expressed, Growth stimulation expressed gene 2, homolog of mouse growth stimulation-expressed, IL-1R4, ILRL1, Interleukin 1 receptor like 1, interleukin 1 receptor related protein, Interleukin-1 receptor-like 1, Protein ST2, T1 protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser 328 |
| Accession | NP_057316.3 |
| Calculated Molecular Weight | 36.3 kDa |
| Tag | C-His |
| Bio-activity | Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind biotinylated human IL1RL1 (isoform A) with a linear range of 0.032-8 μg/ml. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.