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Recombinant Human IL2RG/CD132 Protein (Fc & His Tag)
SKU: PKSH032573-50
Recombinant Human IL2RG/CD132 Protein (Fc & His Tag)
| SKU # | PKSH032573 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IMD, IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, Cytokine receptor common subunit gamma, gammaC, Interleukin-2 receptor subunit gamma, common &, gamma- chain-n, IL-2R&, gamma |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu23-Ala262 |
| Accession | P31785 |
| Calculated Molecular Weight | 29.3 kDa |
| Observed Molecular Weight | 45-85 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
IL2RG contains one fibronectin type-III domain. IL2RG is an important signaling component of many interleukin receptors; including those of interleukin -2; -4; -7 and -21; and is thus referred to as the common gamma chain. IL2RG interacts with SHB upon interleukin stimulation and HTLV-1 accessory protein p12I. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) and severe combined immunodeficiency X-linked T-cell-negative /B-cell-positive / NK-cell-negative (XSCID).