Recombinant Human IMP1/IMPA1 Protein (His Tag)
SKU: PKSH032590-50
Recombinant Human IMP1/IMPA1 Protein (His Tag)
SKU # | PKSH032590 |
Expression Host | E.coli |
Description
Synonyms | IMP 1, IMPA, IMPA1, IMPase 1, Inositol Monophosphatase 1, Inositol-1(or 4)-Monophosphatase 1, Lithium-Sensitive Myo-Inositol Monophosphatase A1 |
Species | Human |
Expression Host | E.coli |
Sequence | Met 1-Asp277 |
Accession | P29218 |
Calculated Molecular Weight | 32.3 kDa |
Observed Molecular Weight | 30 kDa |
Tag | N-His |
Bio-activity | Not validated for activity |
Properties
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.25. |
Reconstitution | Not Applicable |
Background
Inositol Monophosphatase 1 (IMPA1) belongs to the inositol monophosphatase family. IMPA1 is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, IMPA1 can use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA1 has been implicated as the pharmacological target for lithium action in brain. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. In addition, IMPA1 plays a improtant role in intracellular signal transduction.