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Recombinant Human IMPA2/IMPase 2 Protein (His Tag)
SKU: PKSH032591-50
Recombinant Human IMPA2/IMPase 2 Protein (His Tag)
| SKU # | PKSH032591 |
| Expression Host | E.coli |
Description
| Synonyms | IMP 2, IMP.18P, IMPA2, IMPase 2, Inositol Monophosphatase 2, Inositol-1(or 4)-Monophosphatase 2, Myo-Inositol Monophosphatase A2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys288 |
| Accession | O14732 |
| Calculated Molecular Weight | 33.5 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 2mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li(+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.