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Recombinant Human Interleukin-17F/IL-17F Protein (His Tag)(Active)
SKU: PKSH032624-50
Recombinant Human Interleukin-17F/IL-17F Protein (His Tag)(Active)
| SKU # | PKSH032624 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Cytokine ML, Interleukin, CANDF, IL17F, CANDF6, IL-17F, ML-1, ML1, Cytokine ML-1, IL24, IL-24, Interleukin-17F, Interleukin-24 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg31-Gln163 |
| Accession | AAH70124.1 |
| Calculated Molecular Weight | 16.0 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | C-His |
| Bio-activity | Immobilized Mouse IL-17RA-Fc at 1μg/ml (100 μl/well)can bind Human IL-17F-His.The ED50 of Human IL-17F-His is 47.94 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated; but not resting; CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines; including IL-6; IL-8; and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2; TGFB1/TGFB; and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).