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Recombinant Human IPPI2/IDI2 Protein (His Tag)
SKU: PKSH032661-50
Recombinant Human IPPI2/IDI2 Protein (His Tag)
| SKU # | PKSH032661 |
| Expression Host | E.coli |
Description
| Synonyms | IDI2, IPP Isomerase 2, IPPI2, Isopentenyl Pyrophosphate Isomerase 2, Isopentenyl-Diphosphate Delta-Isomerase 2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Val227 |
| Accession | Q9BXS1 |
| Calculated Molecular Weight | 28.9 kDa |
| Observed Molecular Weight | 28-31 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 0.1mM PMSF, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Isopentenyl Pyrophosphate Isomerase 2 (IDI2) belongs to the IPP isomerase type 1 family. Both isozymes, IDI1 and IDI2 are localized to the peroxisome by a PTS1-dependent pathway. IDI2 is expressed in skeletal muscle, which contains one nudix hydrolase domain. IDI2 binds one magnesium per subunit. IDI2 catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). It is reported that IDI2 is regulated independently from IDI1, by a mechanism that may involve PPAR-α.