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Recombinant Human ITGA5 Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human ITGA5 Protein (His Tag)(Active)

SKU: PKSH032600-50

  • £27300
  • Save £3100



Recombinant Human ITGA5 Protein (His Tag)(Active)

 

SKU # PKSH032600
Expression Host HEK293 Cells

 

 

Description

Synonyms CD49 Antigen-Like Family Member E, CD49e, FNRA, Fibronectin Receptor Subunit Alpha, ITGA5, Integrin Alpha-5, Integrin Alpha-F, VLA-5
Species Human
Expression Host HEK293 Cells
Sequence Phe42-Tyr995
Accession P08648
Calculated Molecular Weight 105.1 kDa
Observed Molecular Weight 130 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts; endothelial cells; peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion; ITGA5 participates in cell-surface mediated signalling.