Recombinant Human ITM2B Protein (His Tag)
SKU: PKSH032599-50
Recombinant Human ITM2B Protein (His Tag)
SKU # | PKSH032599 |
Expression Host | HEK293 Cells |
Description
Synonyms | BRI, BRI2, Bri, ITM2B, Immature BRI2, Integral Membrane Protein 2B, Protein E25B, Transmembrane Protein BRI, imBRI2 |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | Tyr76-Ser266 |
Accession | Q9Y287 |
Calculated Molecular Weight | 23.3 kDa |
Observed Molecular Weight | 29-33 kDa |
Tag | C-His |
Bio-activity | Not validated for activity |
Properties
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 25mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 4.5. |
Reconstitution | Not Applicable |
Background
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.