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Recombinant Human Kallikrein 1/KLK1 Protein (His Tag)
SKU: PKSH032664-50
Recombinant Human Kallikrein 1/KLK1 Protein (His Tag)
| SKU # | PKSH032664 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | KLK1, Kallikrein-1, Kidney/Pancreas/Salivary Gland Kallikrein, Tissue Kallikrein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Pro19-Ser262 |
| Accession | AAH05313.1 |
| Calculated Molecular Weight | 28.2 kDa |
| Observed Molecular Weight | 38-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays a role in angiogensis and tumorigenesis.