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Recombinant Human KIR2DL4/CD158D Protein
SKU: PKSH030752-100
Recombinant Human KIR2DL4/CD158D Protein
| SKU # | PKSH030752 |
| Expression Host | CHO Stable Cells |
Description
| Synonyms | CD158 Antigen-Like Family Member D, CD158D, CD158d, G9P, KIR-103AS, KIR103AS, KIR2DL4, Killer Cell Immunoglobulin-Like Receptor 2DL4, Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS |
| Species | Human |
| Expression Host | CHO Stable Cells |
| Sequence | Met 1-His242 |
| Accession | ADY38409.1 |
| Calculated Molecular Weight | 25.1 kDa |
| Observed Molecular Weight | 33-37 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.