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Recombinant Human Lactotransferrin/LTF Protein (His Tag)
SKU: PKSH032679-50
Recombinant Human Lactotransferrin/LTF Protein (His Tag)
| SKU # | PKSH032679 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GIG12, HEL110, HLF2, Kaliocin-1, LF, LTF, Lactoferrin, Lactoferroxin-A, Lactoferroxin-B, Lactoferroxin-C, Lactotransferrin, Talalactoferrin |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly20-Lys711 |
| Accession | AAH15822.1 |
| Calculated Molecular Weight | 77.3 kDa |
| Observed Molecular Weight | 90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Lactotransferrin is a member of the transferrin family that transfer iron to the cells and control the level of free iron in the blood and external secretions. Lactotransferrin is a secreted protein and contains two transferrin-like domains. Lactotransferrin can be cleaved into the following four chains: Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; and Lactoferroxin-C. Lactoferroxin A; Lactoferroxin B; and Lactoferroxin C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors; while Lactoferroxin B and Lactoferroxin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. LTF has antimicrobial activity (bacteriocide; fungicide) and is part of the innate defense; mainly at mucoses.