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Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 2/ LAIR2/CD306 (C-Fc)
SKU: PKSH033932-50
Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 2/ LAIR2/CD306 (C-Fc)
| SKU # | PKSH033932 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD306, LAIR-2, LAIR2, Leukocyte-Associated Immunoglobulin-Like Receptor 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln22-Pro152 |
| Accession | Q6ISS4 |
| Calculated Molecular Weight | 41.0 kDa |
| Observed Molecular Weight | 45-55 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.