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Recombinant Human LL-37 protein (GST tag)
SKU: PDEH100129-100
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Recombinant Human LL-37 protein (GST tag)
| SKU # | PDEH100129 |
| Expression Host | E. coli |
Description
| Synonyms | Cathelicidin antimicrobial peptide;CAMP_HUMAN;CAMP;18 kDa cationic antimicrobial protein;CAP-18;hCAP-18;FALL39;HSD26 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Leu 134-Ser 170 |
| Accession | P49913 |
| Mol_Mass | 29.0 kDa |
| AP_Mol_Mass | 32 kDa |
| Tag | N-GST |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Antimicrobial protein that is an integral component of the innate immune system. Binds to bacterial lipopolysaccharides (LPS). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin. The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro).