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Recombinant Human LSAMP Protein (Fc Tag)(Active)
SKU: PKSH030896-100
Recombinant Human LSAMP Protein (Fc Tag)(Active)
| SKU # | PKSH030896 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | FLJ34254, FLJ35396, FLJ37216, FLJ54658, IGLON3, LAMP |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Asn 315 |
| Accession | Q13449 |
| Calculated Molecular Weight | 59.0 kDa |
| Observed Molecular Weight | 80-85 kDa |
| Tag | C-hFc |
| Bio-activity | Immobilized recombinant human OPCML-His at 10 μg/mL can bind recombinant human LSAMP-Fc with a linear range of 31. 25-250 ng/ml. |
Properties
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions; also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule; serving as a guidance cue for specific patterns of connectivity; which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety; indicating a possible role of LsAMP in the regulation of anxiety.