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Recombinant Human LTA4H Protein (His Tag)
SKU: PKSH032704-50
Recombinant Human LTA4H Protein (His Tag)
| SKU # | PKSH032704 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | LTA-4 hydrolase, LTA4, LTA4H, Leukotriene A(4) hydrolase, Leukotriene A-4 hydrolase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Asp611 |
| Accession | P09960 |
| Calculated Molecular Weight | 70.3 kDa |
| Observed Molecular Weight | 60-70 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM MES, 2mM EDTA, 20% Glycerol, pH 5.0. |
| Reconstitution | Not Applicable |
Background
LTA4H, which is short for Leukotriene A-4 hydrolase, is a 611 aa. protein. It belongs to the peptidase M1 family, and exists in cytoplasm. This protein has at least 4 isforms produced by alternative splicing, and two of them are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. LTA4H involves in lipid metabolism and leukotriene B4 biosynthesis. It is a epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. It also has aminopeptidase activity.