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Recombinant Human LTF/LF protein (His tag)
SKU: PDEH100183-100
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Recombinant Human LTF/LF protein (His tag)
| SKU # | PDEH100183 |
| Expression Host | E. coli |
Description
| Synonyms | Lactotransferrin;Lactoferrin;Talalactoferrin;Kaliocin-1;Lactoferroxin-A;Lactoferroxin-B;Lactoferroxin-C;LTF;LF;GIG12;HEL110;HLF2 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Glu 542- Gln 685 |
| Accession | P02788 |
| Mol_Mass | 15.7 kDa |
| AP_Mol_Mass | 16 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Lactotransferrin is a member of the transferrin family that transfer iron to the cells and control the level of free iron in the blood and external secretions. Lactotransferrin is a secreted protein and contains two transferrin-like domains. Lactotransferrin can be cleaved into the following four chains: Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; and Lactoferroxin-C. Lactoferroxin A; Lactoferroxin B; and Lactoferroxin C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors; while Lactoferroxin B and Lactoferroxin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. LTF has antimicrobial activity (bacteriocide; fungicide) and is part of the innate defense; mainly at mucoses.