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Recombinant Human LYPD3 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human LYPD3 Protein (His Tag)

SKU: PKSH030987-100

  • £52800
  • Save £5900



Recombinant Human LYPD3 Protein (His Tag)

 

SKU # PKSH030987
Expression Host HEK293 Cells

 

Description

Synonyms C4.4A, GPI-Anchored Metastasis-Associated Protein C4.4A Homolog, LYPD3, Ly6/PLAUR Domain-Containing Protein 3, MIG-C4, Matrigel-Induced Gene C4 Protein
Species Human
Expression Host HEK293 Cells
Sequence Met 1-His 286
Accession NP_055215.2
Calculated Molecular Weight 28.3 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

L-selectin (SELL); also known as CD62L; is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins; and consisting of a large; highly glycosylated; extracellular domain; a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a &quot;homing receptor&quot; for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin; slowing leukocyte trafficking through the blood; and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including na&iuml;ve and effector subsets such as regulatory T cells. In addition; L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly; L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.