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Recombinant Human MAA/GSTZ1 Protein (His Tag)
SKU: PKSH032732-50
Recombinant Human MAA/GSTZ1 Protein (His Tag)
| SKU # | PKSH032732 |
| Expression Host | E.coli |
Description
| Synonyms | GSTZ1, GSTZ1-1, Glutathione S-Transferase Zeta 1, MAAI, Maleylacetoacetate Isomerase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ala216 |
| Accession | O43708 |
| Calculated Molecular Weight | 25.2 kDa |
| Observed Molecular Weight | 25-30 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Maleylacetoacetate Isomerase (MAAI) belongs to the Glutathione S-Transferase super-family. MAAI encodes multifunctional enzymes in the detoxification of electrophilic molecules by conjugation with glutathione, for example, mutagens, carcinogens and several therapeutic drugs. MAAI is a bifunctional protein with low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. MAAI can catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. But it has minimal glutathione-conjugating activity with 7-chloro-4-nitrobenz-2-oxa-1, ethacrynic acid 3-diazole and maleylacetoacetate isomerase activity.