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Recombinant Human MR-ProADM protein(His tag)– MSE Supplies LLC

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Recombinant Human MR-ProADM protein(His tag)

SKU: PDEH100087-100

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Recombinant Human MR-ProADM protein(His tag)

 

SKU # PDEH100087
Expression Host E. coli

 

Description

Synonyms AM;ProAM N-terminal 20 peptide;PAMP;ProAM-N20
Species Human
Expression_host E.coli
Sequence Glu45-Val92
Accession P35318
Mol_Mass 31.3 kDa
AP_Mol_Mass 32 kDa
Tag N-GST


Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis


Background

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.