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Recombinant Human Nogo Receptor/NgR Protein (His Tag)
SKU: PKSH033418-50
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Recombinant Human Nogo Receptor/NgR Protein (His Tag)
| SKU # | PKSH033418 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | NOGOR, NgR, Nogo Receptor, Nogo-66 Receptor, RTN4R, Reticulon-4 Receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Cys27-Ser447 |
| Accession | Q9BZR6 |
| Calculated Molecular Weight | 46.3 kDa |
| Observed Molecular Weight | 60-90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a receptor for myelin-derived proteins Nogo; myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMG); NgR mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NgR may be proposed as a potential drug target for treatment of various neurological conditions. Additionally; NgR may play a role in regulating the function of gap junctions.