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Recombinant Human OSMR/IL31RB Protein (aa 28-739, His Tag)
SKU: PKSH032836-50
Recombinant Human OSMR/IL31RB Protein (aa 28-739, His Tag)
| SKU # | PKSH032836 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | PLCA, OSMR, IL-31R-beta, IL-31RB, OSMRB, PLCA1, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, Interleukin-31 Receptor Subunit Beta, Oncostatin-M specific receptor subunit beta, Oncostatin-M-Specific Receptor Subunit Beta |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu28-Ser739 |
| Accession | Q99650 |
| Calculated Molecular Weight | 82.0 kDa |
| Observed Molecular Weight | 132 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Oncostatin-M-Specific Receptor Subunit β (OSMRβ) is a 150 - 180 kDa member of the IL-6 receptor family. OSMRβ associates with gp130 to form the type II OSM receptor, the receptor is responsive to OSM. Gp130 subunit is shared by other IL-6 family cytokine receptors, and OSMRβ associates with gp130-like receptor (GPL) to form a receptor complex responsive to IL-31. The human OSMRβ cDNA encodes a 979 amino acid (aa) precursor, the precursor includes a 27 aa signal sequence, a 712 aa extracellular domain (ECD), a 22 aatransmembrane segment, and a 218 aa cytoplasmic domain. The ECD contains one partial and one complete hematopoietin domain, an Ig-like domain, and three Fibronectin type-III domains.