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Recombinant Human PDIA6 Protein (His Tag)
SKU: PKSH032958-50
Recombinant Human PDIA6 Protein (His Tag)
| SKU # | PKSH032958 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ER Protein 5, ERP5, ERp5, Endoplasmic Reticulum Protein 5, P5, PDIA6, Protein Disulfide Isomerase P5, Protein Disulfide-Isomerase A6, TXNDC7, Thioredoxin Domain-Containing Protein 7 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu20-Leu440 |
| Accession | Q15084 |
| Calculated Molecular Weight | 47.2 kDa |
| Observed Molecular Weight | 52 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1. PDIA6 also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.