Thank you!

Your quote has been successfully submitted!

For products requiring additional information, our team will contact you within 1 business day

Failed

There was an error submitting your quote. Please try again.

Recombinant Human PFKFB1 Protein (His Tag)– MSE Supplies LLC

Free Shipping on MSE PRO Online Orders of $500 or More! U.S. Orders Only * Offer Excludes Hazmat Shipments *

Menu

This product has been added to the cart.

Recombinant Human PFKFB1 Protein (His Tag)

SKU: PKSH032459-50

  • £43300
  • Save £4800



Recombinant Human PFKFB1 Protein (His Tag)

 

SKU # PKSH032459
Expression Host HEK293 Cells

 

 

Description

Synonyms 6-P2ase liver isozyme, 6-bisphosphatase, 6-bisphosphatase 1, 6-phosphofructo-2-kinase/fructose-2, 6PF-2-K/Fru-2, F6PK, Fructose-2, PFKFB1, PFRX
Species Human
Expression Host HEK293 Cells
Sequence Ser2-Tyr471
Accession P16118
Calculated Molecular Weight 55.6 kDa
Observed Molecular Weight 60 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, 1mM EDTA, pH 7.8.
Reconstitution Not Applicable



Background

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.