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Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)
SKU: PKSH030653-50
Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)
| SKU # | PKSH030653 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Beta-Trace Protein, Cerebrin-28, Glutathione-Independent PGD Synthase, Lipocalin-Type Prostaglandin-D Synthase, PDS, PGD2 Synthase, PGDS, PGDS2, PTGDS, Prostaglandin D Synthase, Prostaglandin-D2 Synthase, Prostaglandin-H2 D-Isomerase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala23-Gln190 |
| Accession | P41222 |
| Calculated Molecular Weight | 19.7 kDa |
| Observed Molecular Weight | 20-27 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.