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Recombinant Human PKIB/PKI-β Protein (His Tag)
SKU: PKSH032155-50
Recombinant Human PKIB/PKI-β Protein (His Tag)
| SKU # | PKSH032155 |
| Expression Host | E.coli |
Description
| Synonyms | PKI-beta, PKIB, PRKACN2, cAMP-Dependent Protein Kinase Inhibitor Beta |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys78 |
| Accession | Q9C010 |
| Calculated Molecular Weight | 10.6 kDa |
| Observed Molecular Weight | 16 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity; this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. It may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer.