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Recombinant Human PPIase/PPIL1 Protein (aa 1-166, His Tag)
SKU: PKSH033304-50
Recombinant Human PPIase/PPIL1 Protein (aa 1-166, His Tag)
| SKU # | PKSH033304 |
| Expression Host | E.coli |
Description
| Synonyms | CGI, UNQ, PRO, PPIL, CYPL, PPIase FKBP, Rotamase PPIL, FK506-Binding Protein, Peptidyl-Prolyl Cis-Trans Isomerase FKBP, Peptidyl-Prolyl Cis-Trans Isomerase-Like, PPIL1, CGI-124, CYPL1, PPIase, hCyPX, 23 kDa FK506-Binding Protein, 23 kDa FKBP, FK506-Binding Protein 7, FKBP23, FKBP-23, FKBP7, FKBP-7, Peptidyl-Prolyl Cis-Trans Isomerase FKBP7, Peptidyl-Prolyl Cis-Trans Isomerase-Like 1, PPIase FKBP7, Rotamase, Rotamase PPIL1, UNQ2425, PRO4984, peptidylprolyl isomerase like 1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Gly166 |
| Accession | Q9Y3C6 |
| Calculated Molecular Weight | 20.4 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 (PPIase) belongs to the cyclophilin-type PPIase family. PPIases can accelerate the folding of proteins and catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIase is a ubiquitous protein and has highly expression in heart ;skeletal and muscle. PPIase contains a PPIase cyclophilin-type domain and four Cyclosporin A binding regions. PPIase might play an important role in proliferation of cancer cells through modulation of phosphorylation of stathmin. It is suggested that PPIase can act as as a novel molecular target for colon-cancer therapy.