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Recombinant Human PRL-2/PTP4A2 Protein (GST Tag)
SKU: PKSH030728-100
Recombinant Human PRL-2/PTP4A2 Protein (GST Tag)
| SKU # | PKSH030728 |
| Expression Host | E.coli |
Description
| Synonyms | HH13, HH7-2, HMT, HNMT-S1, HNMT-S2, HU-PP-1, OV-1, PRL-2, PRL2, PTP(CAAXII), PTP4A, PTP4A2, PTPCAAX2, Protein tyrosine phosphatase type IVA 2, Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, ptp-IV1a, ptp-IV1b |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Asn 2-Gln 167 |
| Accession | Q12974-1 |
| Calculated Molecular Weight | 45.9 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM Tris, 0.15M NaCl, 1mM GSH, pH 7.3 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeutic targets. PRL-1, PRL-2, and PRL-3 represent a novel class of protein-tyrosine phosphatase with a C-terminal prenylation motif. They are three closely related intracellular enzymes that possess the PTP active site signature sequence CX 5R. The PRL-2 mRNA is elevated in primary breast tumors relative to matched normal tissue, and also dramatically elevated in metastatic lymph nodes compared with primary tumors. PRL-2 plays a role in breast cancer progression. PRL-2 is a pathogenic molecule in hematopoietic malignancies and suggest its potential as a novel therapeutic target.