Total Price: $0.00
Contact Information
Recombinant Human PROS1/Protein S Protein (His Tag)
SKU: PKSH030881-100
Recombinant Human PROS1/Protein S Protein (His Tag)
| SKU # | PKSH030881 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | PROS, PS21, PS22, PS23, PS24, PS25, PSA, Protein S, THPH5, THPH6 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser676 |
| Accession | P07225 |
| Calculated Molecular Weight | 74.1 kDa |
| Observed Molecular Weight | 69-89 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free, functionally active form and an inactive form complexed with C4b-binding protein. Besides its anticoagulant function, PROS1 also acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S. The interaction of protein S with endothelial cells and particularly its effects on angiogenesis have not yet been analyzed.