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Recombinant Human PTH2/PTRH2 Protein (His Tag)
SKU: PKSH030587-100
Recombinant Human PTH2/PTRH2 Protein (His Tag)
| SKU # | PKSH030587 |
| Expression Host | E.coli |
Description
| Synonyms | BIT1, CFAP37, CGI-147, IMNEPD, PTH, PTH 2, PTH2, PTRH2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gly63-Tyr179 |
| Accession | Q9Y3E5 |
| Calculated Molecular Weight | 14.5 kDa |
| Observed Molecular Weight | 14 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
PTH2, also known as PTRH2, is a mitochondrial protein which belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. When in the cytoplasm, PTRH2 regulates the function of 2 transcriptional regulators, TLE5 and TLE1, thus promoting caspase-independent cell death.