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Recombinant Human RAB11B Protein (His Tag)
SKU: PKSH030533-100
Recombinant Human RAB11B Protein (His Tag)
| SKU # | PKSH030533 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | H-YPT3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly2-Cys215 |
| Accession | ABQ59034.1 |
| Calculated Molecular Weight | 26.3 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The two recurrent dominant mutations in RAB11B leading to a neurodevelopmental syndrome, likely caused by altered GDP/GTP binding that inactivate the protein and induce GEF binding and protein mislocalization.